Framed for assassinating the U.S. president at the end of Season Three, Nikita is the world's most wanted woman - alone, on the run and trying to clear her name. When she unexpectedly reunites with her old team - ex-fiance and mentor Michael, former protege Alex, tech genius Seymour Birkhoff and ex-CIA analyst Ryan Fletcher - they struggle to heal past betrayals while attempting to take down their nemesis Amanda, discovering in the process a vast conspiracy that threatens a global catastrophe. With wild card Sam back on the scene, emotions run high and counterespionage runs deep as Nikita battles to be true to her mission, the people she loves, and herself in the heart-pounding final episodes of this killer espionage series.